Amber Abrams, project manager of the Pan African Clinical Trials Registry based at the The South African Cochrane Centre, based at the South African Medical Research Council. Research interests: clinical trial activity on the African continent, with a special interest in understanding the experiences of clinical trial participants.
Tamara Kredo, principal investigator of the Pan African Clinical Trials Registry, senior specialist scientist and acting manager at the South African Cochrane Centre, based at the South African Medical Research Council.
Research interests: training and conduct of systematic reviews related to HIV/AIDS and other priority areas.
The Pan African Clinical Trials Registry
In 2004, the World Health Assembly called for the development of a network of clinical trial registers to feed data to a single point of access thereby pooling information and creating a system for unambiguous identification of trials (1). The World Health Organization (WHO) developed the International Clinical Trial Registry Platform (ICTRP), as this single point of access, which collects data from the members of the WHO Network of Primary Registries.
Clinical trial registries can curb publication bias or selective reporting by ensuring that trial protocols are transparent and freely available to stakeholders. The registry collects a standard 20-item data set on registered trials before the inception of the trial and recruitment of the first participant. When trials are prospectively registered the outcomes as stated in the protocol can be tracked all the way through the course of the trial thereby ensuring that objectives cannot be changed without a public record of those changes
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